Present Position

Professor and Chairman, Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University

Guest Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

Previous Positions

2015-2019: Chief, Department of Pediatrics, Osaka Hospital, Japan Community Healthcare Organization (JCHO)

Guest Associate Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

2013-2015: Associate Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

2004-2013: Assistant Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

2002-2004: Instructor, Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry

2000-2002: Chief, Department of Pediatrics, Niimi Central Hospital

Visiting Scientist, Okayama University Graduate School of Medicine and Dentistry

1997-2000: Postdoctoral Fellow, Department of Pathology, Washington University School of Medicine, Barnes-Jewish Hospital

1992-1997: PhD Candidate, Okayama University Graduate School of Medicine

1992-1995: Pediatric Residency, Okayama University Hospital

 

Academic Degrees

1997: PhD, Okayama University Graduate School of Medicine

1992: MD, Faculty of Medicine, Okayama University Medical School

 

Licensure and Board Certification

2016: ‎Board Certified Educator, Japan Pediatric Society, number 20957

2007: Certified Endocrine Educator, The Japan Endocrine Society, number 4070005

2006: Board Certified Endocrinologist, The Japan Endocrine Society, number 2060003

1997: Board Certified Pediatrician, Japan Pediatric Society, number 20957

1992: Physician's License, Japan, number 344274

 

Society Memberships

Japan Pediatric Society

Board of Representatives

The Japan Endocrine Society

Councilor

The Japanese Society for Pediatric Endocrinology

Director

Chair (Bone and Mineral Metabolism Committee)

Vice Editor-in-Chief (Clinical Pediatric Endocrinology)

The Japanese Society for Bone and Mineral Research

Councilor

Editorial Board (Journal of Bone and Mineral Metabolism)

The American Society for Bone and Mineral Research

The Endocrine Society

European Society for Paediatric Endocrinology

Asia Pacific Paediatric Endocrine Society

Councilor

Chair (Scientific Program Organising Committee)

Asian Society for Pediatric Research

etc.

 

Honors

2014: Japan Pediatric Society (JPS) Scientific Research Award

2013: Japan Endocrine Society (JES) Research Award

2010: Novo Nordisk Growth & Development Research Award

2006: Outstanding Presentation Award, The Japanese Society for Pediatric Endocrinology (JSPE)

2004: Japan Pediatric Society (JPS) Pfizer Award AAP (American Academy of Pediatrics Exchange Program)

2003: Novo Nordisk Growth Award

1999: Travel Award, The American Society for Bone and Mineral Research (ASBMR)

 

Research Focus & Interests

2019- : Professor and Chairman, Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University

a) Genetics and molecular basis of disorders of growth

b) Optimization and development of new treatment strategies for hypophosphatemic rickets

c) Optimization and development of new treatment strategies for osteogenesis imperfecta

 

2015-2019: Chief, Department of Pediatrics, Osaka Hospital, Japan Community Healthcare Organization (JCHO).

Visiting Academic Staff (2015-2018) / Guest Associate Professor (2019), Department of Pediatrics, Osaka University Graduate School of Medicine

Themes:

a) Optimization and development of new treatment strategies for hypophosphatemic rickets

b) Optimization and development of new treatment strategies for hypophosphatasia.

c) Optimization and development of new treatment strategies for achondroplasia and hypochondroplasia

d) Optimization and development of new treatment strategies for osteogenesis imperfecta

e) Clinical characterization of patients with various skeletal dysplasias

f) Development of new treatments for monocarboxylate transporter 8 (MCT8) deficiency

 

2013-2015: Associate Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

2004-2013: Assistant Professor, Department of Pediatrics, Osaka University Graduate School of Medicine

In collaboration with Dr. Keiichi Ozono

Themes:

a) Determination of cell specific expression and action of thyroid hormone transporters

b) Detailed clinical analysis of patients with MCT8 deficiency

c) Characterization and analysis of an overgrowth syndrome with epiphyseal chondrodysplasia caused by a constitutively active mutation in the natriuretic peptide receptor 2 (NPR2)

d) Biology of fibroblast growth factor 23 in hypophosphatemic rickets and vitamin D deficient rickets

e) Bisphosphonate treatment in osteogenesis imperfecta and its effects on bone and mineral metabolism

f) Growth in growth hormone treated achondroplasia and hypochondroplasia patients

g) Clinical characterization of patients with various skeletal dysplasias

h) Genetic analysis of the PTPN11 gene and functional characterization of the protein tyrosine phosphatase SHP2 in Noonan syndrome patients

 

2002-2004: Instructor, Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry

2000-2002: Visiting Scientist, Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry

In collaboration with Drs. Hiroyuki Tanaka and Yoshiki Seino

Themes:

a) Osteoclast function and molecular mechanism of bone loss and joint destruction in juvenile idiopathic arthritis

b) Molecular mechanisms of bone loss and increased osteoclast function in metastatic rhabdomyosarcoma

c) Bone and mineral metabolism in patients with skeletal dysplasias

 

1997-2000: Postdoctoral fellow under the supervision of Drs. F. Patrick Ross and Steven L. Teitelbaum. Department of Pathology, Washington University School of Medicine, Barnes-Jewish Hospital

Themes:

a) Determination of the molecular mechanisms of osteoclast apoptosis

b) Characterization and biochemical analysis of the osteoporotic phenotype in src homology 2 (SH2)-containing inositol phosphatase (SHIP) 1 deficient mice

c) Determination of integrin specific signaling pathways in osteoclasts

d) Purification and cloning of a factor that induces c-src expression in bone marrow macrophages

 

1996-1997: PhD candidate and Postdoctoral fellow under the supervision of Drs. Hiroyuki Tanaka and Yoshiki Seino. Department of Pediatrics, Okayama University Medical School

Themes:

a) Chromosomal mapping and tissue expression of the inwardly rectifying potassium channels KCNJN1 and KCNJ12

b) FGF/fibroblast growth factor receptor (FGFR) signaling bone cells

 

1994-1996: PhD candidate under the direction of Drs. Nobuya Inagaki and Susumu Seino. Division of Molecular Medicine, Center for Biomedical Science, Chiba University School of Medicine

Themes:

a) Structure and function of inwardly rectifying potassium channels expressed in pancreatic beta cells

b) Cloning and characterization of purinoreceptors

 

Publications

1. Kyakuno M, Nakamori R, Tazawa I, Uemasu H, Namba N, Tsunekawa N, Noce T, Satoh Y, Takeuchi T, Hayashi T. Photoperiod-independent testicular development in the model newt Pleurodeles waltl. Dev Growth Differ. 2021 Jun 16. doi: 10.1111/dgd.12738. Online ahead of print.

 

2. Padidela R, Whyte MP, Glorieux FH, Munns CF, Ward LM, Nilsson O, Portale AA, Simmons JH, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Williams A, Nixon A, Sun W, Chen A, Skrinar A, Imel EA. Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia. Calcif Tissue Int. 2021 May;108(5):622-633. doi: 10.1007/s00223-020-00797-x. Epub 2021 Jan 23.

 

3. Narai S, Kawashima-Sonoyama Y, Fujimoto M, Miura M, Adachi K, Nanba E, Namba N. Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression. Yonago Acta Med. 2021 Jan 20;64(1):57-66. doi: 10.33160/yam.2021.02.009.

 

4. Owada Y, Asano Y, Hanada T, Yasukawa H, Yamaoka M, Mita Y, Namba N†. Newly formulated GROWJECT® is bioequivalent to the prior GROWJECT® formulation and causes less injection-associated pain. Clin Pediatr Endocrinol. 2021;30(1):35-40. doi: 10.1297/cpe.30.35. Epub 2021 Jan 5. †corresponding author

 

5. Harada D, Kashiwagi H, Ueyama K, Oriyama K, Hanioka Y, Sakamoto N, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Yamada H, Tanaka H, Namba N, Seino Y. Monthly intravenous alendronate treatment can maintain bone strength in osteogenesis imperfecta patients following cyclical pamidronate treatment. J Pediatr Endocrinol Metab. 2020 Nov 26;33(11):1391-1397. doi: 10.1515/jpem-2020-0071.

 

6. Kawashima S, Yagi H, Hirano Y, Toki M, Izumi K, Dateki S, Namba N, Kamimaki T, Muroya K, Tanaka T, Fukami M, Kagami M; Japanese SHOX study group. Screening for imprinting disorders in 58 patients with clinically diagnosed idiopathic short stature. J Pediatr Endocrinol Metab. 2020 Aug 31;33(10):1335-1339. doi: 10.1515/jpem-2020-0198.

 

7. Kubota T, Fukumoto S, Cheong HI, Michigami T, Namba N, Ito N, Tokunaga S, Gibbs Y, Ozono K. Long-term outcomes for Asian patients with X-linked hypophosphataemia: rationale and design of the SUNFLOWER longitudinal, observational cohort study. BMJ Open. 2020 Jun 29;10(6):e036367. doi: 10.1136/bmjopen-2019-036367.

 

8. Yokoyama H, Sakaguchi M, Yamada Y, Kitamoto K, Okada S, Kanzaki S, Namba N. Successful Treatment of Cyst Infection in an Infant with Autosomal Dominant Polycystic Kidney Disease Using Trimethoprim/Sulfamethoxazole. Front Pediatr. 2020 Jun 2;8:216. doi: 10.3389/fped.2020.00216.

 

9. Yokoyama H, Okada S, Yamada Y, Kitamoto K, Inaga S, Nakane H, Kaidoh T, Honda K, Kanzaki S, Namba N. Low-vacuum scanning electron microscopy may allow early diagnosis of human renal transplant antibody-mediated rejection. Biomed Res. 2020;41(2):81-90. doi: 10.2220/biomedres.41.81. Published: April 01, 2020. Released: April 19, 2020

 

10. Michigami T, Ohata Y, Fujiwara M, Mochizuki H, Adachi M, Kitaoka T, Kubota T, Sawai H, Namba N, Hasegawa K, Fujiwara I, Ozono K. Clinical Practice Guidelines for Hypophosphatasia. Clin Pediatr Endocrinol. 2020;29(1):9-24. doi: 10.1297/cpe.29.9. Epub 2020 Jan 9.

 

11. Masunaga Y, Inoue T, Yamoto K, Fujisawa Y, Sato Y, Kawashima-Sonoyama Y, Morisada N, Iijima K, Ohata Y, Namba N, Suzumura H, Kuribayashi R, Yamaguchi Y, Yoshihashi H, Fukami M, Saitsu H, Kagami M, Ogata T. IGF2 Mutations: Report of Five Cases, Review of the Literature, and Comparison with H19/IGF2:IG-DMR Epimutations. J Clin Endocrinol Metab. 2020 Jan 1;105(1):116-125. pii: dgz034. doi: 10.1210/clinem/dgz034. Epub 2019 Sep 23

 

12. Ohata Y, Takeyari S, Nakano Y, Kitaoka T, Nakayama H, Bizaoui V, Yamamoto K, Miyata K, Yamamoto K, Fujiwara M, Kubota T, Michigami T, Yamamoto K, Yamamoto T, Namba N, Ebina K, Yoshikawa H, Ozono K. Comprehensive genetic analyses using targeted next-generation sequencing and genotype-phenotype correlations in 53 Japanese patients with osteogenesis imperfecta. Osteoporos Int. 2019 Nov;30(11):2333-2342. doi: 10.1007/s00198-019-05076-6. Epub 2019 Jul 29.

 

13. Ogushi K, Hattori A, Suzuki E, Shima H, Izawa M, Yagasaki H, Horikawa R, Uetake K, Umezawa A, Ishii T, Muroya K, Namba N, Tanaka T, Hirano Y, Yamamoto H, Soneda S, Matsubara K, Kagami M, Miyado M, Fukami M. DNA Methylation Status of SHOX-Flanking CpG Islands in Healthy Individuals and Short Stature Patients with Pseudoautosomal Copy Number Variations. Cytogenet Genome Res. 2019;158(2):56-62. doi: 10.1159/000500468. Epub 2019 Jun 4.

 

14. Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. Lancet. 2019 Jun 15;393(10189):2416-2427. doi: 10.1016/S0140-6736(19)30654-3. Epub 2019 May 16.

 

15. Takeyari S, Takakuwa S, Miyata K, Yamamoto K, Nakayama H, Ohata Y, Fujiwara M, Kitaoka T, Kubota T, Namba N, Sakai N, Ozono K. Metreleptin treatment for congenital generalized lipodystrophy type 4 (CGL4): a case report. Clin Pediatr Endocrinol. 2019;28(1):1-7. doi: 10.1297/cpe.28.1. Epub 2019 Jan 31.

 

16. Islam MS, Namba N†, Ohata Y, Fujiwara M, Nakano C, Takeyari S, Miyata K, Nakano Y, Yamamoto K, Nakayama H, Kitaoka T, Kubota T, Ozono K. Functional analysis of monocarboxylate transporter 8 mutations in Japanese Allan-Herndon-Dudley syndrome patients. Endocr J. 2019 Jan 28;66(1):19-29. doi: 10.1507/endocrj.EJ18-0251. Epub 2018 Oct 25. †corresponding author

 

17. Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N†. A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: clinical course and review of the literature. Clin Pediatr Endocrinol. 2018;27(3):179-186. doi: 10.1297/cpe.27.179. Epub 2018 Jul 31. †corresponding author

 

18. Akiyama T, Kubota T, Ozono K, Michigami T, Kobayashi D, Takeyari S, Sugiyama Y, Noda M, Harada D, Namba N, Suzuki A, Utoyama M, Kitanaka S, Uematsu M, Mitani Y, Matsunami K, Takishima S, Ogawa E, Kobayashi K. Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. Mol Genet Metab. 2018 Sep;125(1-2):174-180. doi: 10.1016/j.ymgme.2018.07.006. Epub 2018 Jul 17.

 

19. Miyashita E, Miyoshi Y, Namba N, Ohta H, Yoshida H, Miyamura T, Hashii Y, Ozono K. Endocrine late effects following allogeneic hematopoietic stem cell transplantation with non-myeloablative conditioning. Journal of Hematopoietic Cell Transplantation. 2018;7(3):90-7. doi: 10.7889/hct-16-033. Epub 2018 Jul 13.

 

20. Ueyama K, Namba N†, Kitaoka T, Yamamoto K, Fujiwara M, Ohata Y, Kubota T, Ozono K. Endocrinological and phenotype evaluation in a patient with acrodysostosis. Clin Pediatr Endocrinol. 2017;26(3):177-182. doi: 10.1297/cpe.26.177. Epub 2017 Jul 27. †corresponding author

 

21. Harada D, Namba N†, Hanioka Y, Ueyama K, Sakamoto N, Nakano Y, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Ishiura Y, Ogitani A, Seino Y. Final adult height in long-term growth hormone-treated achondroplasia patients. Eur J Pediatr. 2017 Jul;176(7):873-879. doi: 10.1007/s00431-017-2923-y. Epub 2017 May 13. †corresponding author

 

22. Yasuda K, Miyoshi Y, Tachibana M, Namba N, Miki K, Nakata Y, Takano T, Ozono K. Relationship between dose of antithyroid drugs and adverse events in pediatric patients with Graves' disease. Clin Pediatr Endocrinol. 2017 Jan;26(1):1-7. doi: 10.1297/cpe.26.1.

 

23. Shima H, Tanaka T, Kamimaki T, Dateki S, Muroya K, Horikawa R, Kanno J, Adachi M, Naiki Y, Tanaka H, Mabe H, Yagasaki H, Kure S, Matsubara Y, Tajima T, Kashimada K, Ishii T, Asakura Y, Fujiwara I, Soneda S, Nagasaki K, Hamajima T, Kanzaki S, Jinno T, Ogata T, Fukami M; Japanese SHOX study group. Systematic molecular analyses of SHOX in Japanese patients with idiopathic short stature and Leri-Weill dyschondrosteosis. J Hum Genet. 2016 Jul;61(7):585-91. doi: 10.1038/jhg.2016.18. Epub 2016 Mar 17.

 

24. Kubota T, Wang W, Miura K, Nakayama H, Yamamoto K, Fujiwara M, Ohata Y, Tachibana M, Kitaoka T, Takakuwa S, Miyoshi Y, Namba N, Ozono K. Serum NT-proCNP levels increased after initiation of GH treatment in patients with achondroplasia/hypochondroplasia. Clin Endocrinol (Oxf). 2016 Jun;84(6):845-50. doi: 10.1111/cen.13025. Epub 2016 Feb 25.

 

25. Yamamoto K, Namba N, Kubota T, Usui T, Takahashi K, Kitaoka T, Fujiwara M, Hori Y, Kogaki S, Oue T, Morii E, Ozono K. Pheochromocytoma complicated by cyanotic congenital heart disease: a case report. Clin Pediatr Endocrinol. 2016 Apr;25(2):59-65. doi: 10.1297/cpe.25.59. Epub 2016 Apr 28.

 

26. Ono E, Ariga M, Oshima S, Hayakawa M, Imai M, Ochiai Y, Mochizuki H, Namba N, Ozono K, Miyata I. Three novel mutations of the MCT8 (SLC16A2) gene: individual and temporal variations of endocrinological and radiological features. Clin Pediatr Endocrinol. 2016 Apr;25(2):23-35. doi: 10.1297/cpe.25.23. Epub 2016 Apr 28.

 

27. Fujiwara M, Kubota T, Wang W, Ohata Y, Miura K, Kitaoka T, Okuzaki D, Namba N, Michigami T, Kitabatake Y, Ozono K. Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2. Bone. 2016 Apr;85:91-8. doi: 10.1016/j.bone.2016.01.024. Epub 2016 Feb 2.

 

28. Wang W, Song MH, Miura K, Fujiwara M, Nawa N, Ohata Y, Kitaoka T, Kubota T, Namba N, Jin DK, Kim OH, Ozono K, Cho TJ. Acromesomelic dysplasia, type maroteaux caused by novel loss-of-function mutations of the NPR2 gene: Three case reports. Am J Med Genet A. 2016 Feb;170(2):426-34. doi: 10.1002/ajmg.a.37463. Epub 2015 Nov 14.

 

29. Endo I, Fukumoto S, Ozono K, Namba N, Inoue D, Okazaki R, Yamauchi M, Sugimoto T, Minagawa M, Michigami T, Nagai M, Matsumoto T. Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases in Japan: prevalence, biochemical data and treatment. Endocr J. 2015 Sep 30;62(9):811-6. doi: 10.1507/endocrj.EJ15-0275. Epub 2015 Jul 1.

 

30. Fukami M, Naiki Y, Muroya K, Hamajima T, Soneda S, Horikawa R, Jinno T, Katsumi M, Nakamura A, Asakura Y, Adachi M, Ogata T, Kanzaki S; Japanese SHOX study group. Rare pseudoautosomal copy-number variations involving SHOX and/or its flanking regions in individuals with and without short stature. J Hum Genet. 2015 Sep;60(9):553-6. doi: 10.1038/jhg.2015.53. Epub 2015 Jun 4.

 

31. Tamura M, Isojima T, Kawashima M, Yoshida H, Yamamoto K, Kitaoka T, Namba N, Oka A, Ozono K, Tokunaga K, Kitanaka S. Detection of Hereditary 1,25-Hydroxyvitamin D-Resistant Rickets Caused by Uniparental Disomy of Chromosome 12 Using Genome-Wide Single Nucleotide Polymorphism Array. PLoS One. 2015 Jul 8;10(7):e0131157. doi: 10.1371/journal.pone.0131157. eCollection 2015.

 

32. Ohata Y, Yamazaki M, Kawai M, Tsugawa N, Tachikawa K, Koinuma T, Miyagawa K, Kimoto A, Nakayama M, Namba N, Yamamoto H, Okano T, Ozono K, Michigami T. Elevated Fibroblast Growth Factor 23 Exerts Its Effects on Placenta and Regulates Vitamin D Metabolism in Pregnancy of Hyp Mice. J Bone Miner Res. 2014 Jul;29(7):1627-38. doi: 10.1002/jbmr.2186.

 

33. Kitaoka T, Miyoshi Y, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Takagi M, Hasegawa T, Jüppner H, Ozono K. Two Japanese familial cases of Caffey disease with and without the common COL1A1 mutation and normal bone density, and review of the literature. Eur J Pediatr. 2014 Jun;173(6):799-804. doi: 10.1007/s00431-013-2252-8. Epub 2014 Jan 4.

 

34. Kubota T, Kitaoka T, Miura K, Fujiwara M, Ohata Y, Miyoshi Y, Yamamoto K, Takeyari S, Yamamoto T, Namba N, Ozono K. Serum fibroblast growth factor 23 is a useful marker to distinguish vitamin D-deficient rickets from hypophosphatemic rickets. Horm Res Paediatr. 2014;81(4):251-7. doi: 10.1159/000357142. Epub 2014 Feb 26.

 

35. Ozono K, Hasegawa Y, Minagawa M, Adachi M, Namba N, Kazukawa I, Kitaoka T, Asakura Y, Shimura A, Naito Y. Therapeutic use of oral sodium phosphate (phosribbon^(®) combination granules) in hereditary hypophosphatemic rickets. Clin Pediatr Endocrinol. 2014 Jan;23(1):9-15. doi: 10.1292/cpe.23.9. Epub 2014 Feb 3.

 

36. Miura K, Kim OH, Lee HR, Namba N, Michigami T, Yoo WJ, Choi IH, Ozono K, Cho TJ. Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene. Am J Med Genet A. 2014 Jan;164(1):156-63. Epub 2013 Nov 20.

 

37. Fujiwara M, Namba N†, Miura K, Kitaoka T, Hirai H, Kondou H, Shimotsuji T, Numakura C, Ozono K. Detection and characterization of two novel mutations in the HNF4A gene in maturity-onset diabetes of the young 1 in two Japanese families. Horm Res Paediatr. 2013;79(4):220-6. Epub 2013 May 1. †corresponding author

 

38. Fujiwara M, Namba N, Ozono K, Arisaka O, Yokoya S, and Committee on Drugs, Japanese Society for Pediatric Endocrinology. Treatment of hypophosphatemic rickets with phosphate and active vitamin D in Japan: a questionnaire-based survey. Clin Pediatr Endocrinol. 2013 Jan;22(1):9-14.

 

39. Miyoshi Y, Ohta H, Namba N, Tachibana M, Miyamura T, Miyashita E, Hashii Y, Oue T, Isobe A, Tsutsui T, Kimura T, Ozono K. Low serum concentrations of anti-müllerian hormone are common in 53 female childhood cancer survivors. Horm Res Paediatr. 2013;79(1):17-21. Epub 2012 Dec 28.

 

40. Ozono K, Namba N, Kubota T, Kitaoka T, Miura K, Ohata Y, Fujiwara M, Miyoshi Y, Michigami T. Pediatric aspects of skeletal dysplasia. Pediatr Endocrinol Rev. 2012 Oct;10 Suppl 1:35-43.

 

41. Miura K, Namba N, Fujiwara M, Ohata Y, Ishida H, Kitaoka T, Kubota T, Hirai H, Higuchi C, Tsumaki N, Yoshikawa H, Sakai N, Michigami T, Ozono K. An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS One. 2012;7(8):e42180. Epub 2012 Aug 3.

 

42. Abe S*, Namba N*†, Abe M, Fujiwara M, Aikawa T, Kogo M, Ozono K. Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes. Endocrinology. 2012 Aug;153(8):4049-58. Epub 2012 Jun 19. *equal contribution, †corresponding author

 

43. Narazaki R, Ihara K, Namba N, Matsuzaki H, Ozono K, Hara T. Linear nevus sebaceous syndrome with hypophosphatemic rickets with elevated FGF-23. Pediatr Nephrol. 2012 May;27(5):861-3. Epub 2011 Dec 29.

 

44. Kitaoka T, Namba N, Miura K, Kubota T, Ohata Y, Fujiwara M, Hirai H, Yamamoto T, Ozono K. Decrease in serum FGF23 levels after intravenous infusion of pamidronate in patients with osteogenesis imperfecta. J Bone Miner Metab. 2011 Sep;29(5):598-605. Epub 2011 Feb 23.

 

45. Miura K, Umegaki N, Kitaoka T, Kubota T, Namba N, Etani Y, Hirai H, Kogaki S, Nakajima S, Takahashi Y, Tamai K, Katayama I, Ozono K. A male patient with humoral hypercalcemia of malignancy (HHM) with leukocytosis caused by cutaneous squamous cell carcinoma resulting from recessive dystrophic epidermolysis bullosa. Clin Pediatr Endocrinol. 2011 Jul;20(3):65-71.

 

46. Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K. Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood. J Clin Endocrinol Metab. 2011 Jun;96(6):E943-7. Epub 2011 Mar 16.

 

47. Yamazaki Y, Imura A, Urakawa I, Shimada T, Murakami J, Aono Y, Hasegawa H, Yamashita T, Nakatani K, Saito Y, Okamoto N, Kurumatani N, Namba N, Kitaoka T, Ozono K, Sakai T, Hataya H, Ichikawa S, Imel EA, Econs MJ, Nabeshima Y. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun. 2010 Jul 30;398(3):513-8. Epub 2010 Jul 1.

 

48. Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T, Morii E, Aoki T, Murakami M, Mushiake S, Ozono K. Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. Eur J Pediatr. 2010 Feb;169(2):215-21. Epub 2009 Jun 23.

 

49. Kitaoka T, Namba N, Kim JY, Kubota T, Miura K, Miyoshi Y, Hirai H, Kogo M, Ozono K. A Japanese Male Patient with 'Fibular Aplasia, Tibial Campomelia and Oligodactyly': An Additional Case Report. Clin Pediatr Endocrinol. 2009 Jul;18(3):81-86.

 

50. Miyoshi Y, Ohta H, Hashii Y, Tokimasa S, Namba N, Mushiake S, Hara J, Ozono K. Endocrinological analysis of 122 Japanese childhood cancer survivors in a single hospital. Endocr J. 2008 Dec;55(6):1055-63. Epub 2008 Aug 22.

 

51. Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K. Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd. J Bone Miner Res. 2008 Oct;23(10):1661-71.

 

52. Fukumoto S, Namba N, Ozono K, Yamauchi M, Sugimoto T, Michigami T, Tanaka H, Inoue D, Minagawa M, Endo I, Matsumoto T. Causes and differential diagnosis of hypocalcemia--recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan. Endocr J. 2008 Oct;55(5):787-94. Epub 2008 May 19.

 

53. Namba N, Etani Y, Kitaoka T, Nakamoto Y, Nakacho M, Bessho K, Miyoshi Y, Mushiake S, Mohri I, Arai H, Taniike M, Ozono K. Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter. Eur J Pediatr. 2008 Jul;167(7):785-91. Epub 2007 Sep 25.

 

54. Miyoshi Y, Akagi M, Agarwal AK, Namba N, Kato-Nishimura K, Mohri I, Yamagata M, Nakajima S, Mushiake S, Shima M, Auchus RJ, Taniike M, Garg A, Ozono K. Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings. Clin Genet. 2008 Jun;73(6):535-44. Epub 2008 Apr 22.

 

55. Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T. Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement. Bone. 2008 Jun;42(6):1235-9. Epub 2008 Mar 5.

 

56. Kawai M, Mushiake S, Bessho K, Murakami M, Namba N, Kokubu C, Michigami T, Ozono K. Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem Biophys Res Commun. 2007 Nov 16;363(2):276-82. Epub 2007 Aug 27.

 

57. Senoo H, Iida S, Kishino M, Namba N, Aikawa T, Kogo M. Solitary congenital granular cell lesion of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul;104(1):e45-8.

 

58. Kawai M, Namba N, Mushiake S, Etani Y, Nishimura R, Makishima M, Ozono K. Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway. J Mol Endocrinol. 2007 Feb;38(1-2):19-34.

 

59. Ozono K, Michigami T, Namba N, Nakajima S, Yamamoto T. Molecular bases of diseases characterized by hypophosphatemia and phosphaturia: New understanding. Clin Pediatr Endocrinol. 2006 Oct;15(4):129-135.

 

60. Kubota T, Namba N, Kurotobi S, Kogaki S, Hirai H, Kitaoka T, Nakajima S, Ozono K. Beneficial effect of oral bisphosphonate treatment on bone loss induced by chronic administration of furosemide without alteration of its administration and urinary calcium loss. Clin Pediatr Endocrinol. 2006 Jul;15(3):101-107.

 

61. Miyoshi Y, Santo Y, Tachikawa K, Namba N, Hirai H, Mushiake S, Nakajima S, Michigami T, Ozono K. Lack of puberty despite elevated estradiol in a 46,XY phenotypic female with Frasier syndrome. Endocr J. 2006 Jun;53(3):371-6. Epub 2006 May 23.

 

62. Kubota T, Kotani T, Miyoshi Y, Santo Y, Hirai H, Namba N, Shima M, Shimizu K, Nakajima S, Ozono K. A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin D Deficiency. Clin Pediatr Endocrinol. 2006 Jan;15(1):23-28.

 

63. Kubota T, Namba N, Nakajima S, Arai H, Ozono K. A Case with Marshall-Smith Syndrome without Life-threatening Complications. Clin Pediatr Endocrinol 14 Suppl 24:63-67. 2005.

 

64. Kataoka K, Namba N, Inoue M, Morishima T, Oono T, Iwatsuki K, Tanaka H. A Dyskeratosis Congenita (DKC) Patient Treated with Growth Hormone. Clin Pediatr Endocrinol 14 Suppl 24:77-80. 2005.

 

65. Kanazawa H, Tanaka H, Inoue M, Yamanaka Y, Namba N, Seino Y. Efficacy of growth hormone therapy for patients with skeletal dysplasia. J Bone Miner Metab. 2003;21(5):307-10.

 

66. Feng X, Takeshita S, Namba N, Wei S, Teitelbaum SL, Ross FP. Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function. Endocrinology. 2002 Dec;143(12):4868-74.

 

67. Takeshita S*, Namba N*, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med. 2002 Sep;8(9):943-9. Epub 2002 Aug 5. *equal contribution

 

68. Gupta A, Tenenhouse HS, Hoag HM, Wang D, Khadeer MA, Namba N, Feng X, Hruska KA. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 2001 Nov;29(5):467-76.

 

69. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res. 2001 Sep 10;269(1):73-87.

 

70. Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, Pacifici R. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest. 2000 Nov;106(10):1229-37.

 

71. McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Lam J, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest. 2000 Feb;105(4):433-40.

 

72. Inoue M, Namba N, Chappel J, Teitelbaum SL, Ross FP. Granulocyte macrophage-colony stimulating factor reciprocally regulates alphav-associated integrins on murine osteoclast precursors. Mol Endocrinol. 1998 Dec;12(12):1955-62.

 

73. Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y. The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1. Cytogenet Cell Genet. 1997;79(1-2):85-7.

 

74. Seino S, Inagaki N, Namba N, Wang CH, Kotake K, Nagashima K, Miki T, Aguilar-Bryan L, Bryan J, Gonoi T. Molecular basis of functional diversity of ATP-sensitive K+ channels. Jpn J Physiol. 1997;47 Suppl 1:S3-4.

 

75. Seino S, Inagaki N, Namba N, Gonoi T. Molecular biology of the beta-cell ATP-sensitive K+ channel. Diabetes Reviews 4:177-190. 1996.

 

76. Namba N, Inagaki N, Gonoi T, Seino Y, Seino S. Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2. FEBS Lett. 1996 May 20;386(2-3):211-4.

 

77. Wang CZ, Namba N, Gonoi T, Inagaki N, Seino S. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Biochem Biophys Res Commun. 1996 Mar 7;220(1):196-202.

 

78. Inagaki N, Gonoi T, Clement JP 4th, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science. 1995 Nov 17;270(5239):1166-70.

 

79. Inagaki N, Tsuura Y, Namba N, Masuda K, Gonoi T, Horie M, Seino Y, Mizuta M, Seino S. Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart. J Biol Chem. 1995 Mar 17;270(11):5691-4.

 

80. Namba N, Kubo T, Ono T, Tanaka T, Kanzaki S, Seino Y. Bone Mineral Status in Turner Syndrome. Clin Pediatr Endocrinol. 1995 Dec;4 Suppl 6:131-136.