Guo-Li Ming
Research in Dr. Guo-li Ming's laboratory centers on understanding molecular mechanisms underlying neurodevelopment and how its dysregulation may contribute to developmental neurological disorders. The lab uses a combination of experimental approaches that include molecular biology, biochemistry, mouse genetics, imaging, electrophysiology, electron microscopy, optogenetic manipulations, next generation sequencing, and behavioral tests to study neural development. We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons.
Details: https://www.med.upenn.edu/minglab/
Representative papers
1. Jimenez-Cyrus D, Adusumilli VS, Stempel MH, Maday S, Ming GL, Song H, Bond AM. Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state. Nature Medicine. 2024 February 29
2. Bagley SJ, Logyn M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nature Medicine. 2024 February 29
3. Xue X, Kim YS, Ponce-Arias AI, O'Laughlin R, Yan RZ, Kobayashi N, Tshuva RY, Tsai YH, Sun S, Zheng Y, Liu Y, Wong FCK, Surani A, Spence JR, Song H, Ming Gl, Reiner O, Fu J. A patterned human neural tube model using microfluidic gradients. Nature. 2024 February 29
4. Reynolds DE, Sun Y, Wang X, Vallapureddy P, Lim J, Pan M, Del Castillo AF, Carlson JCT, Sellmyer MA, Nasrallah M, Binder Z, O'Rourke DM, Ming GL, Song H, Ko J. Live Organoid Cyclic Imaging. Advanced Science. 2024 February 07
5. Zhang F, Yoon K, Zhang DY, Kim NS, Ming GL, Song H. Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification. Cell Stem Cell. 2023;30(3):300-311.e11. doi:10.1016/j.stem.2023.01.007
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