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药物性损伤相关研究成果

一、药物性肝损伤

1. A protective mechanism of licorice (Glycyrrhiza uralensis): Isoliquiritigenin stimulates detoxification system via Nrf2 activation，龚慧，颜苗，李焕德等


2. Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway，颜苗，张毕奎等


3. Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway，颜苗等


4. Curcumin attenuates isoniazid-induced hepatotoxicity by upregulating the SIRT1/PGC-1α/NRF1 pathway，彭文兴等


5. Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity，王义坤等


6. Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1，王义坤等


二、药物代谢毒性

1. A potential mechanism underlying atypical antipsychotics-induced lipid disturbances，蔡骅琳等


2. A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits，蔡骅琳等


3. Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling，蔡骅琳等


4. Olanzapine-induced lipid disturbances: A potential mechanism through the gut microbiota-brain axis，张毕奎，蔡骅琳等


5. An LC–MS/MS method for determination of bioactive components of licorice and Semen Strychni in rat plasma: application to a pharmacokinetics study，方平飞，李焕德等


6. Investigation of the detoxification effect of licorice on Semen Strychni-induced acute toxicity in rats using a HPLC-Q-TOF/MS-based metabolomics approach，方平飞，李焕德等


7. Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats，方平飞等


8. Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation，方平飞等



三、药物心脏毒性

1. Involvement of ROS/NLRP3 Inflammasome Signaling Pathway in Doxorubicin‑Induced Cardiotoxicity，张毕奎，李文群等


2. Involvement of Abnormal Gut Microbiota Composition and Function in Doxorubicin-Induced Cardiotoxicity，张毕奎，李文群等


3. Noncoding RNA-Associated Competing Endogenous RNA Networks in Doxorubicin-Induced Cardiotoxicity，李文群等